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Phenobarbital sodium could be administered intramuscularly or intravenously being an anticonvulsant for emergency use. When administered intravenously, it might require 15 or maybe more minutes in advance of achieving peak concentrations in the Mind. For that reason, injecting phenobarbital sodium until finally the convulsions end may well trigger the brain level to exceed that needed to Regulate the convulsions and cause critical barbiturate-induced despair.

There are actually, even so, no adequate and effectively-controlled reports in Expecting Girls. For the reason that animal reproduction experiments are certainly not constantly predictive of human reaction, this drug should be made use of throughout pregnancy only if Evidently wanted.

Phenobarbital can be a barbituric acid spinoff and occurs as white, odorless, smaller crystals or crystalline powder that is very a little bit soluble in h2o; soluble in alcohol, in ether, As well as in remedies of fixed alkali hydroxides and carbonates; sparingly soluble in chloroform.

On the other hand, using barbiturates as sedatives while in the postoperative surgical time period and as adjuncts to cancer chemotherapy is well recognized.

Reports of infants suffering from extensive-term barbiturate exposure in utero provided the acute withdrawal syndrome of seizures here and hyperirritability from delivery to your delayed onset of nearly 14 times. (See DRUG ABUSE AND DEPENDENCE.)

The concomitant use of alcohol or other CNS depressants might create additive CNS depressant effects.

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On the other hand, the use of barbiturates website as sedatives inside the postoperative surgical interval and as adjuncts to most cancers chemotherapy is nicely proven.

When administered intravenously, it may well involve 15 or even more minutes right before reaching peak concentrations in the brain.

This outcome is completely reversible unless hypoxic destruction happens. Consideration needs to be provided to the potential for barbiturate intoxication even in cases that seem to contain trauma.

Phenobarbital is often a barbituric acid derivative for oral administration and occurs to be a white, odorless, a bit bitter powder that is certainly soluble in chloroform, check here freely soluble in alcohol or ether, and a little bit soluble in water.

Phenobarbital Sodium Injection, USP is actually a sterile Remedy for intramuscular or gradual intravenous administration as a protracted-acting barbiturate.

Fetal blood levels solution maternal blood levels next parenteral administration. Withdrawal indications take place in read more infants born to Women of all ages who get barbiturates through the very last trimester of pregnancy (see DRUG ABUSE AND DEPENDENCE). If phenobarbital is applied for the duration of pregnancy or In case the affected individual becomes Expecting even though having this drug, the affected person really should be apprised in the prospective hazard to your fetus.